PRLR Antibody (Center)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
|Application ||WB, E|
|Calculated MW||69506 Da|
|Antigen Region||147-179 aa|
|Other Names||Prolactin receptor, PRL-R, PRLR|
|Target/Specificity||This PRLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-179 amino acids from the Central region of human PRLR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRLR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in breast, placenta, kidney, liver and pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Boutin J.-M., et al. Mol. Endocrinol. 3:1455-1461(1989).
Kline J.B., et al. J. Biol. Chem. 274:35461-35468(1999).
Hu Z.-Z., et al. J. Clin. Endocrinol. Metab. 84:1153-1156(1999).
Hu Z.Z., et al. J. Biol. Chem. 276:41086-41094(2001).
Kline J.B., et al. Mol. Endocrinol. 16:2310-2322(2002).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.