|Application ||WB, E|
|Calculated MW||27388 Da|
|Other Names||Cob(I)yrinic acid a, c-diamide adenosyltransferase, mitochondrial, Cob(I)alamin adenosyltransferase, Methylmalonic aciduria type B protein, MMAB|
|Target/Specificity||This MMAB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 50-81 amino acids from the Central region of human MMAB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMAB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA.|
|Tissue Location||Expressed in liver and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Dobson C.M.,et al.Hum. Mol. Genet. 11:3361-3369(2002).
Leal N.A.,et al.J. Biol. Chem. 278:9227-9234(2003).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Schubert H.L.,et al.Biochemistry 45:15188-15196(2006).
Martinez M.A.,et al.Mol. Genet. Metab. 84:317-325(2005).
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