|Application ||WB, E|
|Other Accession||P41565, P70404, P41564, Q58CP0|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||42794 Da|
|Other Names||Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, Isocitric dehydrogenase subunit gamma, NAD(+)-specific ICDH subunit gamma, IDH3G|
|Target/Specificity||This IDH3G antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 50-83 amino acids from the N-terminal region of human IDH3G.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IDH3G Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.|
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Provided below are standard protocols that you may find useful for product applications.
Brenner V.,et al.Genomics 44:8-14(1997).
Kim Y.-O.,et al.J. Biol. Chem. 274:36866-36875(1999).
Ross M.T.,et al.Nature 434:325-337(2005).
Simpson J.C.,et al.EMBO Rep. 1:287-292(2000).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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