Purified Rabbit Polyclonal Antibody (Pab)
|Application ||WB, E|
|Calculated MW||76616 Da|
|Other Names||GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1|
|Target/Specificity||This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 250-285 amino acids from human.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HUMAN-GAB1(Y259) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Holgado-Madruga M.,et al.Nature 379:560-564(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Brdicka T.,et al.J. Exp. Med. 196:1617-1626(2002).
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