|Application ||WB, E|
|Calculated MW||158537 Da|
|Other Names||Attractin, DPPT-L, Mahogany homolog, ATRN, KIAA0548, MGCA|
|Target/Specificity||This ATRN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the N-terminal region of human ATRN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATRN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted|
|Tissue Location||Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes|
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Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).
Tang W.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:6025-6030(2000).
Duke-Cohan J.S.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Duke-Cohan J.S.,et al.J. Biol. Chem. 270:14107-14114(1995).
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