|Application ||WB, E|
|Calculated MW||86830 Da|
|Other Names||Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3|
|Target/Specificity||This TSHR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 217-252 amino acids from the Central region of human TSHR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSHR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690)|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Nagayama Y.,et al.Biochem. Biophys. Res. Commun. 165:1184-1190(1989).
Libert F.,et al.Biochem. Biophys. Res. Commun. 165:1250-1255(1989).
Misrahi M.,et al.Biochem. Biophys. Res. Commun. 166:394-403(1990).
Frazier A.L.,et al.Mol. Endocrinol. 4:1264-1276(1990).
Graves P.N.,et al.Biochem. Biophys. Res. Commun. 187:1135-1143(1992).
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