|Application ||WB, E|
|Calculated MW||120675 Da|
|Other Names||Extracellular calcium-sensing receptor, CaSR, Parathyroid cell calcium-sensing receptor 1, PCaR1, CASR, GPRC2A, PCAR1|
|Target/Specificity||This CASR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1009-1045 amino acids from the C-terminal region of human CASR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CASR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:7759551). The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta|
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Provided below are standard protocols that you may find useful for product applications.
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
Pearce S.H.S.,et al.Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
Garrett J.E.,et al.J. Biol. Chem. 270:12919-12925(1995).
Aida K.,et al.Biochem. Biophys. Res. Commun. 214:524-529(1995).
Freichel M.,et al.Endocrinology 137:3842-3848(1996).
Aida K.,et al.J. Clin. Endocrinol. Metab. 80:2594-2598(1995).
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