|Application ||WB, E|
|Calculated MW||124504 Da|
|Other Names||SLIT-ROBO Rho GTPase-activating protein 3, srGAP3, Mental disorder-associated GAP, Rho GTPase-activating protein 14, WAVE-associated Rac GTPase-activating protein, WRP, SRGAP3, ARHGAP14, KIAA0411, KIAA1156, MEGAP, SRGAP2|
|Target/Specificity||This SRGAP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 956-989 amino acids from the C-terminal region of human SRGAP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SRGAP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARHGAP14, KIAA0411, KIAA1156, MEGAP, SRG|
|Function||GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.|
|Tissue Location||Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
Soderling S.H.,et al.Nat. Cell Biol. 4:970-975(2002).
Endris V.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:11754-11759(2002).
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Wong K.,et al.Cell 107:209-221(2001).
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