|Application ||WB, E|
|Calculated MW||43519 Da|
|Other Names||Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor, ADRB3, ADRB3R, B3AR|
|Target/Specificity||This ADRB3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 216-249 amino acids from the Central region of human ADRB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADRB3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed mainly in adipose tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Emorine L.J.,et al.Science 245:1118-1121(1989).
van Spronsen A.,et al.Eur. J. Biochem. 213:1117-1124(1993).
Lelias J.M.,et al.FEBS Lett. 324:127-130(1993).
Kopatz S.A.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
Granneman J.G.,et al.Mol. Pharmacol. 42:964-970(1992).
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