|Application ||WB, E|
|Calculated MW||48076 Da|
|Other Names||Cysteine-rich PAK1 inhibitor, CRIPak, CRIPAK|
|Target/Specificity||This CRIPAK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-165 amino acids from the Central region of human CRIPAK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRIPAK Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.|
|Cellular Location||Cytoplasm. Membrane. Nucleus. Note=Translocated to the nuclear compartment upon hormonal treatment by estrogen|
|Tissue Location||Widely expressed with a highest expression observed in trachea, prostate and adrenal glands. Expressed in many cancer cell lines including breast cancer cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Talukder A.H.,et al.Oncogene 25:1311-1319(2006).
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