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CERS4 Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

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  • FC - CERS4 Antibody (N-Term) AP21979a
    Overlay histogram showing Hela cells stained with AP21979a (green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (AP21979a, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(OH191631) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • WB - CERS4 Antibody (N-Term) AP21979a
    All lanes : Anti-CERS4 Antibody (N-Term) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: HT-1080 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: LNCaP whole cell lysate Lane 5: PC-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 46 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HA82
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Additional Information
Other Names Ceramide synthase 4, CerS4, LAG1 longevity assurance homolog 4, CERS4, LASS4
Target/Specificity This CERS4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-51 amino acids from human CERS4.
Dilution FC~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCERS4 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CERS4
Synonyms LASS4
Function May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).
Cellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein EMBL; AK022151; BAB13972.1; -; mRNA EMBL; AC022146; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471139; EAW68940.1; -; Genomic_DNA EMBL; CH471139; EAW68941.1; -; Genomic_DNA EMBL; CH471139; EAW68942.1; -; Genomic_DNA EMBL; CH471139; EAW68945.1; -; Genomic_DNA EMBL; BC009828; AAH09828.1; -; mRNA CCDS; CCDS12197.1; - RefSeq; NP_078828.2; NM_024552.2 RefSeq; XP_011526592.1; XM_011528290.2 RefSeq; XP_011526593.1; XM_011528291.2 RefSeq; XP_011526594.1; XM_011528292.2 RefSeq; XP_011526595.1; XM_011528293.2 RefSeq; XP_011526596.1; XM_011528294.2 RefSeq; XP_011526597.1; XM_011528295.2 RefSeq; XP_016882792.1; XM_017027303.1 RefSeq; XP_016882793.1; XM_017027304.1 RefSeq; XP_016882794.1; XM_017027305.1 UniGene; Hs.515111; - ProteinModelPortal; Q9HA82; - SMR; Q9HA82; - BioGrid; 122740; 2 IntAct; Q9HA82; 34 STRING; 9606.ENSP00000251363; - SwissLipids; SLP:000000699; - iPTMnet; Q9HA82; - PhosphoSitePlus; Q9HA82; - BioMuta; CERS4; - DMDM; 296434561; - EPD; Q9HA82; - MaxQB; Q9HA82; - PaxDb; Q9HA82; - PeptideAtlas; Q9HA82; - PRIDE; Q9HA82; - ProteomicsDB; 81384; - DNASU; 79603; - Ensembl; ENST00000251363; ENSP00000251363; ENSG00000090661 Ensembl; ENST00000559450; ENSP00000453509; ENSG00000090661 GeneID; 79603; - KEGG; hsa:79603; - UCSC; uc002mjg.4; human CTD; 79603; - DisGeNET; 79603; - EuPathDB; HostDB:ENSG00000090661.11; - GeneCards; CERS4; - HGNC; HGNC:23747; CERS4 HPA; CAB033734; - HPA; HPA054729; - MIM; 615334; gene neXtProt; NX_Q9HA82; - OpenTargets; ENSG00000090661; - PharmGKB; PA134915173; - eggNOG; KOG1607; Eukaryota eggNOG; COG5058; LUCA GeneTree; ENSGT00550000074401; - HOGENOM; HOG000231977; - HOVERGEN; HBG052310; - InParanoid; Q9HA82; - KO; K04710; - OMA; LYHESWL; - OrthoDB; EOG091G0BWM; - PhylomeDB; Q9HA82; - TreeFam; TF314319; - Reactome; R-HSA-1660661; Sphingolipid de novo biosynthesis GenomeRNAi; 79603; - PRO; PR:Q9HA82; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000090661; - CleanEx; HS_LASS4; - ExpressionAtlas; Q9HA82; baseline and differential Genevisible; Q9HA82; HS GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0050291; F:sphingosine N-acyltransferase activity; IBA:GO_Central GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central GO; GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR001356; Homeobox_dom InterPro; IPR016439; Lag1/Lac1-like InterPro; IPR006634; TLC-dom PANTHER; PTHR12560; PTHR12560; 1 Pfam; PF00046; Homeobox; 1 Pfam; PF03798; TRAM_LAG1_CLN8; 1 PIRSF; PIRSF005225; LAG1_LAC1; 1 SMART; SM00724; TLC; 1 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS50071; HOMEOBOX_2; 1 PROSITE; PS50922; TLC; 1 1: Evidence at protein level; Complete proteome; DNA-binding; Endoplasmic reticulum; Homeobox; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 394 Ceramide synthase 4 /FTId=PRO_0000185512 TRANSMEM 32 52 Helical. TRANSMEM 140 160 Helical. TRANSMEM 179 199 Helical. TRANSMEM 209 229 Helical. TRANSMEM 260 280 Helical. TRANSMEM 304 324 Helical. DOMAIN 131 332 TLC. {ECO:0000255|PROSITE- ProRule:PRU00205} DNA_BIND 67 128 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} MOD_RES 342 342 Phosphoserine {ECO:0000250|UniProtKB:Q9D6J1} MOD_RES 349 349 Phosphoserine {ECO:0000250|UniProtKB:Q9D6J1} MOD_RES 350 350 Phosphoserine {ECO:0000250|UniProtKB:Q9D6J1} VARIANT 119 119 R -> Q (in dbSNP:rs17159388) /FTId=VAR_034065 VARIANT 301 301 G -> S (in dbSNP:rs2288413) /FTId=VAR_019556 VARIANT 353 353 A -> V (in dbSNP:rs17160348) /FTId=VAR_060263 VARIANT 366 366 A -> T (in dbSNP:rs36259) {ECO:0000269|Ref.3} /FTId=VAR_019557 VARIANT 379 379 R -> Q (in dbSNP:rs17160349) /FTId=VAR_060264 SEQUENCE 394 AA; 46399 MW; DAA12AA386ED2802 CRC64; MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL AMRLAFERFI GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL SLLAAQCGLT LQQTQRWFRR RRNQDRPQLT KKFCEASWRF LFYLSSFVGG LSVLYHESWL WAPVMCWDRY PNQTLKPSLY WWYLLELGFY LSLLIRLPFD VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD SSDYLLEACK MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS EEAAAAQEPL QLKNGAAGGP RPAPTDGPRS RVAGRLTNRH TTAT
Research Areas
Citations (0)

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May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).


Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 325.00
$ 109.00
Cat# AP21979a
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