|Application ||WB, E|
|Calculated MW||71110 Da|
|Other Names||Sodium-dependent neutral amino acid transporter B(0)AT1, Solute carrier family 6 member 19, System B(0) neutral amino acid transporter AT1, SLC6A19, B0AT1|
|Target/Specificity||This SLC6A19 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 544-575 amino acids from human SLC6A19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC6A19 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Robust expression in kidney and small intestine, with minimal expression in pancreas. Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
Kleta R.,et al.Nat. Genet. 36:999-1002(2004).
Seow H.F.,et al.Nat. Genet. 36:1003-1007(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Broer S.,et al.J. Clin. Invest. 118:3881-3892(2008).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.