|Application ||WB, E|
|Calculated MW||36382 Da|
|Other Names||C1GALT1-specific chaperone 1, C38H2-like protein 1, C38H2-L1, Core 1 beta1, 3-galactosyltransferase 2, C1Gal-T2, C1GalT2, Core 1 beta3-Gal-T2, Core 1 beta3-galactosyltransferase-specific molecular chaperone, C1GALT1C1, COSMC|
|Target/Specificity||This C1GALT1C1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 26-60 amino acids from human C1GALT1C1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C1GALT1C1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Ubiquitously expressed. Abundantly expressed in salivary gland, stomach, small intestine, kidney, and testis and at intermediate levels in whole brain, cerebellum, spinal cord, thymus, spleen, trachea, lung, pancreas, ovary, and uterus|
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Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).
Kudo T.,et al.J. Biol. Chem. 277:47724-47731(2002).
Kudo T.,et al.J. Biol. Chem. 281:24999-24999(2006).
Ju T.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:16613-16618(2002).
Rubboli F.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
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