|Application ||WB, FC, E|
|Calculated MW||108626 Da|
|Other Names||Chloride channel protein 1, ClC-1, Chloride channel protein, skeletal muscle, CLCN1, CLC1|
|Target/Specificity||This CLCN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the human region of human CLCN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLCN1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Predominantly expressed in skeletal muscles.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Steinmeyer K.,et al.EMBO J. 13:737-743(1994).
Scherer S.W.,et al.Science 300:767-772(2003).
Koch M.C.,et al.Science 257:797-800(1992).
George A.L. Jr.,et al.Nat. Genet. 3:305-310(1993).
Lorenz C.,et al.Hum. Mol. Genet. 3:941-946(1994).
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