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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Methionine Aminopeptidase 2 (METAP2) Antibody (C-term)   

Methionine Aminopeptidase 2 (METAP2) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Methionine Aminopeptidase 2 (METAP2) Antibody (C-term) AP2320b
    Western blot analysis of METAP2 Antibody (C-term) (Cat.#AP2320b) in 293 cell line lysates (35ug/lane). METAP2 (arrow) was detected using the purified Pab.
  • IHC-P - Methionine Aminopeptidase 2 (METAP2) Antibody (C-term) AP2320b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with METAP2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50579
Other Accession P38062, O08663, Q3ZC89, NP_006829
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52892 Da
Antigen Region 437-467 aa
Additional Information
Gene ID 10988
Other Names Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
Target/Specificity This Methionine Aminopeptidase 2 (METAP2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-467 amino acids from the C-terminal region of human Methionine Aminopeptidase 2 (METAP2).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMethionine Aminopeptidase 2 (METAP2) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
Function Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes
Research Areas
Citations (0)

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The ADP-ribosylation factor (Arf) family are highly conserved members of the Ras superfamily of regulatory GTP-binding proteins. Arf proteins participate in routing of intracellular proteins to and within the Golgi complex. Cellular functions include maintenance of organelle integrity, coat protein assembly, as an activator of phospholipase D. The Arf family is divided functionally into the Arf and the Arf-like (Arl) proteins. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization.


Wang, J., et al., Biochemistry 42(17):5035-5042 (2003).
Datta, R., et al., Exp. Cell Res. 283(2):237-246 (2003).
Endo, H., et al., J. Biol. Chem. 277(29):26396-26402 (2002).
Kanno, T., et al., Lab. Invest. 82(7):893-901 (2002).
Li, X., et al., Biochem. Biophys. Res. Commun. 227(1):152-159 (1996).

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$ 325.00
$ 109.00
Cat# AP2320b
Availability: In Stock
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