- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Other Accession||P85834, Q8BFR5, P49410|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||49542 Da|
|Antigen Region||75-104 aa|
|Other Names||Elongation factor Tu, mitochondrial, EF-Tu, P43, TUFM|
|Target/Specificity||This TUFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the N-terminal region of human TUFM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TUFM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.|
Provided below are standard protocols that you may find useful for product applications.
TUFM is a protein which participates in protein translation in mitochondria. This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Valente,L., et.al., Biochim. Biophys. Acta 1792 (8), 791-795 (2009)
Bogenhagen,D.F., et.al., J. Biol. Chem. 283 (6), 3665-3675 (2008)
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