|Application ||WB, IHC-P, E|
|Other Accession||Q8R081, F1LQ48|
|Calculated MW||64133 Da|
|Antigen Region||461-490 aa|
|Other Names||Heterogeneous nuclear ribonucleoprotein L, hnRNP L, HNRNPL, HNRPL|
|Target/Specificity||This HNRPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 461-490 amino acids from the C-terminal region of human HNRPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HNRPL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules|
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Provided below are standard protocols that you may find useful for product applications.
HNRPL is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.
Hahm,B., et.al., FEBS Lett. 425 (3), 401-406 (1998)
Funke,B., et.al., Nucleic Acids Res. 24 (19), 3821-3828 (1996)
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