|Application ||DB, E|
|Other Accession||Q9QYY0, A6QLU3|
|Calculated MW||76616 Da|
|Other Names||GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1|
|Target/Specificity||This Gab1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y659 of human Gab1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Gab1(Y659) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Gab1 is a member of the IRS1-like multisubstrate docking protein family. This protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.
Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004).
Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004).
Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004).
Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003).
Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003).
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