|Application ||DB, E|
|Calculated MW||201278 Da|
|Other Names||Tuberin, Tuberous sclerosis 2 protein homolog, Tsc2|
|Target/Specificity||This rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-rat TSC2(T1373) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). May also play a role in microtubule-mediated protein transport (PubMed:16707451). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (PubMed:9045618).|
|Tissue Location||CNS, uterus, heart, skeletal muscle, kidney and spleen|
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Provided below are standard protocols that you may find useful for product applications.
acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD].
Larson, Y., et al. J. Biol. Chem. 285(32):24987-24998(2010)
Sajankila, S.P., et al. Mol. Cell. Biochem. 338 (1-2), 233-239 (2010) :
Inoue, H., et al. Biosci. Biotechnol. Biochem. 73(11):2488-2493(2009)
Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009)
Shiono, M., et al. Oncogene 27(52):6690-6697(2008)
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