|Application ||WB, IHC-P, FC, E|
|Calculated MW||92027 Da|
|Antigen Region||176-204 aa|
|Other Names||Advillin, p92, AVIL|
|Target/Specificity||This AVIL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-204 amino acids from the N-terminal region of human AVIL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AVIL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection. Cell projection, axon|
|Tissue Location||Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
AVIL is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia.
Piana, S., et al. J. Mol. Biol. 375(2):460-470(2008)
Vermeulen, W., et al. Protein Sci. 13(5):1276-1287(2004)
Tumer, Z., et al. Gene 288 (1-2), 179-185 (2002)
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