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EREG Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • IHC-P - EREG Antibody (C-term) AP4798b
    AP4798b staining EREG in Human brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
  • WB - EREG Antibody (C-term) AP4798b
    Anti-EREG Antibody (C-term)at 1:2000 dilution + A549 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 19 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - EREG Antibody (C-term) AP4798b
    All lanes : Anti-EREG Antibody (C-term) at 1:1000 dilution Lane 1: A549 whole cell lysates Lane 2: human placenta lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 19 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - EREG Antibody (C-term) AP4798b
    Anti-EREG Antibody (C-term)at 1:2000 dilution + U-87 MG whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 19 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - EREG Antibody (C-term) AP4798b
    Western blot analysis of lysates from A549, HepG2, U-87 MG cell line (from left to right), using EREG Antibody (C-term)(Cat. #AP4798b). AP4798b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
  • WB - EREG Antibody (C-term) AP4798b
    Western blot analysis of EREG Antibody (C-term) (Cat. #AP4798b) in HepG2 cell line lysates (35ug/lane). EREG (arrow) was detected using the purified Pab.
  • IHC-P - EREG Antibody (C-term) AP4798b
    EREG Antibody (C-term) (Cat. #AP4798b) IHC analysis in formalin fixed and paraffin embedded colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the EREG Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14944
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 137-165 aa
Additional Information
Other Names Proepiregulin, Epiregulin, EPR, EREG
Target/Specificity This EREG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the C-terminal region of human EREG.
Dilution IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEREG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).
Cellular Location Epiregulin: Secreted, extracellular space
Tissue Location In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon EMBL; D30783; BAA22146.1; -; mRNA EMBL; AK314959; BAG37463.1; -; mRNA EMBL; CR541887; CAG46685.1; -; mRNA EMBL; CH471057; EAX05709.1; -; Genomic_DNA EMBL; BC136404; AAI36405.1; -; mRNA EMBL; BC136405; AAI36406.1; -; mRNA CCDS; CCDS3564.1; - RefSeq; NP_001423.1; NM_001432.2 UniGene; Hs.115263; - PDB; 1K36; NMR; -; A=63-108 PDB; 1K37; NMR; -; A=63-108 PDB; 5E8D; X-ray; 2.50 A; A=38-108 PDB; 5WB7; X-ray; 2.94 A; E/F/G/H=56-116 PDBsum; 1K36; - PDBsum; 1K37; - PDBsum; 5E8D; - PDBsum; 5WB7; - ProteinModelPortal; O14944; - SMR; O14944; - BioGrid; 108381; 5 IntAct; O14944; 3 STRING; 9606.ENSP00000244869; - iPTMnet; O14944; - PhosphoSitePlus; O14944; - BioMuta; EREG; - jPOST; O14944; - MaxQB; O14944; - PaxDb; O14944; - PeptideAtlas; O14944; - PRIDE; O14944; - ProteomicsDB; 48327; - DNASU; 2069; - Ensembl; ENST00000244869; ENSP00000244869; ENSG00000124882 GeneID; 2069; - KEGG; hsa:2069; - UCSC; uc003hie.2; human CTD; 2069; - DisGeNET; 2069; - EuPathDB; HostDB:ENSG00000124882.3; - GeneCards; EREG; - HGNC; HGNC:3443; EREG HPA; HPA054373; - MIM; 602061; gene neXtProt; NX_O14944; - OpenTargets; ENSG00000124882; - PharmGKB; PA27856; - eggNOG; ENOG410IXV0; Eukaryota eggNOG; ENOG410YNFA; LUCA GeneTree; ENSGT00510000048748; - HOGENOM; HOG000059635; - HOVERGEN; HBG005601; - InParanoid; O14944; - KO; K09784; - OMA; CTALVQM; - OrthoDB; 1420179at2759; - PhylomeDB; O14944; - TreeFam; TF336145; - Reactome; R-HSA-1227986; Signaling by ERBB2 Reactome; R-HSA-1236394; Signaling by ERBB4 Reactome; R-HSA-1250196; SHC1 events in ERBB2 signaling Reactome; R-HSA-1250342; PI3K events in ERBB4 signaling Reactome; R-HSA-1250347; SHC1 events in ERBB4 signaling Reactome; R-HSA-1251985; Nuclear signaling by ERBB4 Reactome; R-HSA-1257604; PIP3 activates AKT signaling Reactome; R-HSA-177929; Signaling by EGFR Reactome; R-HSA-179812; GRB2 events in EGFR signaling Reactome; R-HSA-180292; GAB1 signalosome Reactome; R-HSA-180336; SHC1 events in EGFR signaling Reactome; R-HSA-182971; EGFR downregulation Reactome; R-HSA-1963640; GRB2 events in ERBB2 signaling Reactome; R-HSA-1963642; PI3K events in ERBB2 signaling Reactome; R-HSA-212718; EGFR interacts with phospholipase C-gamma Reactome; R-HSA-2219530; Constitutive Signaling by Aberrant PI3K in Cancer Reactome; R-HSA-5638303; Inhibition of Signaling by Overexpressed EGFR Reactome; R-HSA-5673001; RAF/MAP kinase cascade Reactome; R-HSA-6785631; ERBB2 Regulates Cell Motility Reactome; R-HSA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Reactome; R-HSA-8847993; ERBB2 Activates PTK6 Signaling Reactome; R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis Reactome; R-HSA-8856828; Clathrin-mediated endocytosis Reactome; R-HSA-8863795; Downregulation of ERBB2 signaling SIGNOR; O14944; - ChiTaRS; EREG; human EvolutionaryTrace; O14944; - GeneWiki; Epiregulin; - GenomeRNAi; 2069; - PRO; PR:O14944; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000124882; Expressed in 122 organ(s), highest expression level in buccal mucosa cell Genevisible; O14944; HS GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005615; C:extracellular space; IDA:UniProtKB GO; GO:0005887; C:integral component of plasma membrane; TAS:UniProtKB GO; GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB GO; GO:0008083; F:growth factor activity; IBA:GO_Central GO; GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome GO; GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome GO; GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome GO; GO:0009653; P:anatomical structure morphogenesis; TAS:UniProtKB GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW GO; GO:0009887; P:animal organ morphogenesis; TAS:UniProtKB GO; GO:0007267; P:cell-cell signaling; IDA:UniProtKB GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:UniProtKB GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB GO; GO:0038128; P:ERBB2 signaling pathway; TAS:Reactome GO; GO:0007143; P:female meiotic nuclear division; ISS:UniProtKB GO; GO:0030216; P:keratinocyte differentiation; TAS:UniProtKB GO; GO:0043616; P:keratinocyte proliferation; IDA:UniProtKB GO; GO:0042700; P:luteinizing hormone signaling pathway; ISS:UniProtKB GO; GO:0000165; P:MAPK cascade; TAS:Reactome GO; GO:0009299; P:mRNA transcription; IDA:UniProtKB GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB GO; GO:0050680; P:negative regulation of epithelial cell proliferation; TAS:UniProtKB GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; IDA:UniProtKB GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB GO; GO:0001556; P:oocyte maturation; ISS:UniProtKB GO; GO:0001550; P:ovarian cumulus expansion; ISS:UniProtKB GO; GO:0030728; P:ovulation; ISS:UniProtKB GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB GO; GO:0042108; P:positive regulation of cytokine biosynthetic process; IDA:UniProtKB GO; GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB GO; GO:0045740; P:positive regulation of DNA replication; IDA:UniProtKB GO; GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB GO; GO:0048146; P:positive regulation of fibroblast proliferation; IDA:UniProtKB GO; GO:0045089; P:positive regulation of innate immune response; ISS:UniProtKB GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; ISS:UniProtKB GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB GO; GO:0042327; P:positive regulation of phosphorylation; IDA:UniProtKB GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:UniProtKB GO; GO:0051897; P:positive regulation of protein kinase B signaling; TAS:Reactome GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB GO; GO:0048160; P:primary follicle stage; ISS:UniProtKB GO; GO:2000145; P:regulation of cell motility; TAS:Reactome GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl GO; GO:0042060; P:wound healing; TAS:UniProtKB InterPro; IPR013032; EGF-like_CS InterPro; IPR000742; EGF-like_dom InterPro; IPR015497; EGF_rcpt_ligand PANTHER; PTHR10740; PTHR10740; 1 PROSITE; PS00022; EGF_1; 1 PROSITE; PS01186; EGF_2; 1 PROSITE; PS50026; EGF_3; 1 1: Evidence at protein level; 3D-structure; Angiogenesis; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; EGF-like domain; Glycoprotein; Growth factor; Membrane; Mitogen; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix SIGNAL 1 29 CHAIN 30 169 Proepiregulin /FTId=PRO_0000302800 PROPEP 30 62 {ECO:0000250|UniProtKB:Q61521, ECO:0000250|UniProtKB:Q9Z0L5} /FTId=PRO_0000007556 CHAIN 63 108 Epiregulin /FTId=PRO_0000007557 PROPEP 109 169 Removed in mature form. /FTId=PRO_0000007558 TOPO_DOM 60 119 Extracellular. TRANSMEM 120 140 Helical. TOPO_DOM 141 169 Cytoplasmic. DOMAIN 64 104 EGF-like. {ECO:0000255|PROSITE- ProRule:PRU00076} COMPBIAS 145 152 Arg/Lys-rich (basic) CARBOHYD 47 47 N-linked (GlcNAc...) asparagine DISULFID 68 81 {ECO:0000255|PROSITE-ProRule:PRU00076, ECO:0000269|PubMed:14572630} DISULFID 76 92 {ECO:0000255|PROSITE-ProRule:PRU00076, ECO:0000269|PubMed:14572630} DISULFID 94 103 {ECO:0000255|PROSITE-ProRule:PRU00076, ECO:0000269|PubMed:14572630} VARIANT 42 42 G -> A (in a breast cancer sample; somatic mutation) /FTId=VAR_035833 VARIANT 147 147 R -> Q (in dbSNP:rs35275884) /FTId=VAR_033827 STRAND 65 67 {ECO:0000244|PDB:5WB7} HELIX 70 72 {ECO:0000244|PDB:5E8D} TURN 73 75 {ECO:0000244|PDB:5E8D} STRAND 79 84 {ECO:0000244|PDB:5E8D} TURN 85 88 {ECO:0000244|PDB:5E8D} STRAND 89 94 {ECO:0000244|PDB:5E8D} STRAND 98 100 {ECO:0000244|PDB:5E8D} SEQUENCE 169 AA; 19044 MW; 17F3926ADFB2BDEE CRC64; MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV
Research Areas
Citations (0)

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EREG is a member of the epidermal growth factor family. EREG can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.


Ben-Ami, I., et al. Hum. Reprod. 24(1):176-184(2009)
Cho, M.C., et al. Biochem. Biophys. Res. Commun. 377(3):832-837(2008)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008)

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Cat# AP4798b
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