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SYTL2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SYTL2 Antibody (Center) AP4801c
    Western blot analysis of SYTL2 Antibody (Center) (Cat. #AP4801c) in Hela cell line lysates (35ug/lane). SYTL2 (arrow) was detected using the purified Pab.
  • IHC-P - SYTL2 Antibody (Center) AP4801c
    SYTL2 Antibody (Center) (Cat. #AP4801c) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SYTL2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - SYTL2 Antibody (Center) AP4801c
    SYTL2 Antibody (Center) (Cat. #AP4801c) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HCH5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 104930 Da
Antigen Region 840-868 aa
Additional Information
Gene ID 54843
Other Names Synaptotagmin-like protein 2, Breast cancer-associated antigen SGA-72M, Exophilin-4, SYTL2, KIAA1597, SGA72M, SLP2, SLP2A
Target/Specificity This SYTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-868 amino acids from the Central region of human SYTL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYTL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYTL2
Synonyms KIAA1597, SGA72M, SLP2, SLP2A
Function Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
Cellular Location Isoform 1: Cytoplasm. Cell membrane Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.
Tissue Location Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.
Research Areas
Citations (0)

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SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery.


Menasche, G., et al. Blood 112(13):5052-5062(2008)
Kesari, A., et al. Am. J. Pathol. 173(5):1476-1487(2008)
Chavas, L.M., et al. Structure 16(10):1468-1477(2008)

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Cat# AP4801c
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