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TOX3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TOX3 Antibody (Center) AP4814c
    Western blot analysis of TOX3 Antibody (Center) (Cat. #AP4814c) in mouse stomach tissue lysates (35ug/lane). TOX3 (arrow) was detected using the purified Pab.
  • IHC-P - TOX3 Antibody (Center) AP4814c
    TOX3 Antibody (Center) (Cat. #AP4814c) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TOX3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • WB - TOX3 Antibody (Center) AP4814c
    Western blot analysis of TOX3 Antibody (Center) Pab (Cat. #AP4814c) pre-incubated without(lane 1) and with(lane 2) blocking peptide in MDA-MB453 cell line lysate. TOX3 Antibody (Center) (arrow) was detected using the purified Pab.
  • WB - TOX3 Antibody (Center) AP4814c
    Western blot analysis of TOX3 Antibody (Center) Pab (Cat. #AP4814c) pre-incubated without(lane 1) and with(lane 2) blocking peptide in mouse lung tissue lysate. TOX3 Antibody (Center) (arrow) was detected using the purified Pab.
  • FC - TOX3 Antibody (Center) AP4814c
    TOX3 Antibody (Center) (Cat. #AP4814c) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15405
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 63342 Da
Antigen Region 214-242 aa
Additional Information
Gene ID 27324
Other Names TOX high mobility group box family member 3, CAG trinucleotide repeat-containing gene F9 protein, Trinucleotide repeat-containing gene 9 protein, TOX3, CAGF9, TNRC9
Target/Specificity This TOX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-242 amino acids from the Central region of human TOX3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTOX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOX3
Synonyms CAGF9, TNRC9
Function Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
Cellular Location Nucleus.
Tissue Location Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe
Citations ( 0 )


TOX3 contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer.


Wacholder, S., et al. N. Engl. J. Med. 362(11):986-993(2010)
Odefrey, F., et al. Cancer Res. 70(4):1449-1458(2010)
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 18(11):3044-3048(2009)
Stacey, S.N., et al. Nat. Genet. 39(7):865-869(2007)

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$ 325.00
$ 109.00
Cat# AP4814c
Availability: In Stock
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