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ENPP7 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ENPP7 Antibody (Center) AP4923c
    Western blot analysis of ENPP7 Antibody (Center) (Cat. #AP4923c) in HL-60 cell line lysates (35ug/lane). ENPP7 (arrow) was detected using the purified Pab.
  • FC - ENPP7 Antibody (Center) AP4923c
    ENPP7 Antibody (Center) (Cat. #AP4923c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UWV6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51494 Da
Antigen Region 286-313 aa
Additional Information
Gene ID 339221
Other Names Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, E-NPP 7, NPP-7, Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-SMase, ENPP7 {ECO:0000312|EMBL:AAH414532}
Target/Specificity This ENPP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-313 amino acids from the Central region of human ENPP7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsENPP7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENPP7 {ECO:0000312|EMBL:AAH41453.2}
Function Converts sphingomyelin to ceramide and phosphocholine (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:28292932). Has also phospholipase C activity and can cleave phosphocholine from palmitoyl lyso-phosphatidylcholine (PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774).
Cellular Location Cell membrane; Single-pass type I membrane protein Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin (PubMed:15205117) Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex
Tissue Location Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.
Research Areas
Citations (0)

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ENPP7 converts sphingomyelin to ceramide. ENPP7 also has phospholipase C activity toward palmitoyl lyso-phosphocholine. ENPP7 does not appear to have nucleotide pyrophosphatase activity.


Wu, J., et al. Biochem. J. 386 (PT 1), 153-160 (2005)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Wu, J., et al. Carcinogenesis 25(8):1327-1333(2004)

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$ 325.00
$ 109.00
Cat# AP4923c
Availability: In Stock
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