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ANR49 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ANR49 Antibody  (Center) AP4966c
    Western blot analysis of ANR49 Antibody (Center) (Cat. #AP4966c) in Jurkat cell line lysates (35ug/lane). ANR49 (arrow) was detected using the purified Pab.
  • IHC-P - ANR49 Antibody  (Center) AP4966c
    ANR49 Antibody (Center) (Cat. #AP4966c) IHC analysis in formalin fixed and paraffin embedded human lymph carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ANR49 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - ANR49 Antibody  (Center) AP4966c
    ANR49 Antibody (Center) (Cat. #AP4966c) flow cytometric analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WVL7
Other Accession NP_060174
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 80-109 aa
Additional Information
Other Names Ankyrin repeat domain-containing protein 49, Fetal globin-inducing factor, ANKRD49, FGIF
Target/Specificity This ANR49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the Central region of human ANR49.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsANR49 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANKRD49
Synonyms FGIF
Function Induces HBG1 expression (PubMed:16131492, PubMed:11162141). May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF- kappaB pathway (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q8VE42}.
Tissue Location Widely expressed in fetus, at a high level in fetal liver, brain and lung. EMBL; AF025354; AAK60412.1; -; mRNA EMBL; AK000196; BAA91003.1; -; mRNA EMBL; AL833977; CAD38821.2; -; mRNA EMBL; BC017798; AAH17798.1; -; mRNA CCDS; CCDS8300.1; - RefSeq; NP_060174.2; NM_017704.2 RefSeq; XP_016873430.1; XM_017017941.1 UniGene; Hs.29052; - ProteinModelPortal; Q8WVL7; - SMR; Q8WVL7; - BioGrid; 120201; 10 DIP; DIP-61280N; - IntAct; Q8WVL7; 5 STRING; 9606.ENSP00000303518; - iPTMnet; Q8WVL7; - PhosphoSitePlus; Q8WVL7; - BioMuta; ANKRD49; - DMDM; 74751554; - EPD; Q8WVL7; - jPOST; Q8WVL7; - MaxQB; Q8WVL7; - PaxDb; Q8WVL7; - PeptideAtlas; Q8WVL7; - PRIDE; Q8WVL7; - ProteomicsDB; 74802; - DNASU; 54851; - Ensembl; ENST00000302755; ENSP00000303518; ENSG00000168876 Ensembl; ENST00000544612; ENSP00000440396; ENSG00000168876 GeneID; 54851; - KEGG; hsa:54851; - UCSC; uc001pew.4; human CTD; 54851; - EuPathDB; HostDB:ENSG00000168876.8; - GeneCards; ANKRD49; - HGNC; HGNC:25970; ANKRD49 HPA; HPA040273; - HPA; HPA048137; - neXtProt; NX_Q8WVL7; - OpenTargets; ENSG00000168876; - PharmGKB; PA142672615; - eggNOG; KOG0512; Eukaryota eggNOG; COG0666; LUCA GeneTree; ENSGT00390000003919; - HOGENOM; HOG000021411; - HOVERGEN; HBG054416; - InParanoid; Q8WVL7; - KO; K21439; - OMA; ACKWNNA; - OrthoDB; 1546307at2759; - PhylomeDB; Q8WVL7; - TreeFam; TF351259; - ChiTaRS; ANKRD49; human GenomeRNAi; 54851; - PRO; PR:Q8WVL7; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000168876; Expressed in 225 organ(s), highest expression level in bone marrow ExpressionAtlas; Q8WVL7; baseline and differential Genevisible; Q8WVL7; HS GO; GO:0005634; C:nucleus; IC:UniProtKB GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW CDD; cd00204; ANK; 1 Gene3D;; -; 1 InterPro; IPR002110; Ankyrin_rpt InterPro; IPR020683; Ankyrin_rpt-contain_dom InterPro; IPR036770; Ankyrin_rpt-contain_sf Pfam; PF00023; Ank; 1 Pfam; PF12796; Ank_2; 1 PRINTS; PR01415; ANKYRIN SMART; SM00248; ANK; 4 SUPFAM; SSF48403; SSF48403; 1 PROSITE; PS50297; ANK_REP_REGION; 1 PROSITE; PS50088; ANK_REPEAT; 2 1: Evidence at protein level; ANK repeat; Complete proteome; Differentiation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Spermatogenesis CHAIN 1 239 Ankyrin repeat domain-containing protein 49 /FTId=PRO_0000244585 REPEAT 73 103 ANK 1 REPEAT 107 136 ANK 2 REPEAT 140 169 ANK 3 REPEAT 173 206 ANK 4 MOD_RES 49 49 Phosphoserine CONFLICT 25 25 N -> S (in Ref. 1; AAK60412) CONFLICT 201 201 K -> R (in Ref. 2; BAA91003) SEQUENCE 239 AA; 27290 MW; 97103467E8F1EA50 CRC64; MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD EDEEQDDKNE EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH VNTRDEDEYT PLHRAAYSGH LDIVQELIAQ GADVHAVTVD GWTPLHSACK WNNTRVASFL LQHDADINAQ TKGLLTPLHL AAGNRDSKDT LELLLMNRYV KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS
Citations (0)

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Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Blau, C.A., et al. J. Biol. Chem. 280(44):36642-36647(2005)
Pitts, S.A., et al. Hum. Mol. Genet. 10(11):1155-1162(2001)
Yang, Y., et al. Blood Cells Mol. Dis. 27(1):1-15(2001)

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$ 325.00
$ 109.00
Cat# AP4966c
Availability: In Stock
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