|Application ||WB, FC, E|
|Calculated MW||92924 Da|
|Antigen Region||636-664 aa|
|Other Names||Protein EFR3 homolog A, Protein EFR3-like, EFR3A, KIAA0143|
|Target/Specificity||This EFR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-664 amino acids from the C-terminal region of human EFR3A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EFR3A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825).|
|Cellular Location||Cell membrane; Lipid-anchor Cytoplasm, cytosol Note=Palmitoylation anchors the protein to the plasma membrane (PubMed:23229899, PubMed:25380825, PubMed:26571211). A small amount is observed in the cytosol (PubMed:25380825)|
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Munemoto, Y., et al. Brain Res. Mol. Brain Res. 128(2):131-140(2004)
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