|Reactivity||Human, Mouse, Rat|
|Calculated MW||23 KDa|
|Antigen Region||189-211 aa|
|Other Names||Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane|
|Tissue Location||Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis|
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Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells.
Swisshelm K.L.,et al.Gene 226:285-295(1999).
Mitic L.M.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Halford S.,et al.Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F.,et al.Hum. Genet. 107:249-256(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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