|Calculated MW||40 KDa|
|Antigen Region||21-50 aa|
|Other Names||Melatonin receptor type 1B, Mel-1B-R, Mel1b receptor, MTNR1B|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in retina and less in brain and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Reppert S.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:8734-8738(1995).
Ebisawa T.,et al.Neurosci. Lett. 280:29-32(2000).
King M.M.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
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