|Reactivity||Human, Mouse, Rat|
|Calculated MW||29,27 KDa|
|Antigen Region||230-254 aa|
|Other Names||14-3-3 protein epsilon, 14-3-3E, YWHAE|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).|
|Cellular Location||Nucleus. Cytoplasm. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Conklin D.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7892-7896(1995).
Chong S.S.,et al.Genome Res. 6:735-741(1996).
Jin D.-Y.,et al.Nature 382:308-308(1996).
Han D.,et al.Biochem. Biophys. Res. Commun. 396:401-406(2010).
Luk S.C.W.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
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