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UBXN6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - UBXN6 Antibody  (C-term) AP5085b
    Anti-UBXN6 Antibody (C-term) at 1:2000 dilution + Human testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - UBXN6 Antibody  (C-term) AP5085b
    Western blot analysis of UBXN6 Antibody (C-term) (Cat. #AP5085b) in mouse kidney tissue lysates (35ug/lane).UBXN6 (arrow) was detected using the purified Pab.
  • IHC-P - UBXN6 Antibody  (C-term) AP5085b
    UBXN6 Antibody (C-term) (Cat. #AP5085b) IHC analysis in formalin fixed and paraffin embedded mouse testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the UBXN6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BZV1
Other Accession Q2KIJ6
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49754 Da
Antigen Region 281-309 aa
Additional Information
Gene ID 80700
Other Names UBX domain-containing protein 6, UBX domain-containing protein 1, UBXN6, UBXD1, UBXDC2
Target/Specificity This UBXN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the C-terminal region of human UBXN6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUBXN6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBXN6 (HGNC:14928)
Function May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).
Cellular Location Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein Note=Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622)
Tissue Location Enhanced expression in testis.
Research Areas
Citations (0)

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UBXN6 acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. UBXN6 is MDM2 stabilization leads to MDM2-dependent TP53 degradation.


Nagahama, M., et al. Biochem. Biophys. Res. Commun. 382(2):303-308(2009)
Kern, M., et al. Biochem. Biophys. Res. Commun. 380(2):303-307(2009)
Madsen, L., et al. Int. J. Biochem. Cell Biol. 40(12):2927-2942(2008)

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$ 325.00
$ 109.00
Cat# AP5085b
Availability: In Stock
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