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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KLHL24 Antibody (Center)   

KLHL24 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KLHL24 Antibody (Center) AP5238c
    KLHL24 Antibody (Center) (Cat. #AP5238c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).  This demonstrates the KLHL24 antibody detected the KLHL24 protein (arrow).
  • IHC-P - KLHL24 Antibody (Center) AP5238c
    KLHL24 Antibody (Center) (Cat. #AP5238c) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KLHL24 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6TFL4
Other Accession Q56A24, Q8BRG6
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68361 Da
Antigen Region 182-211 aa
Additional Information
Gene ID 54800
Other Names Kelch-like protein 24, Kainate receptor-interacting protein for GluR6, KRIP6, Protein DRE1, KLHL24, DRE1
Target/Specificity This KLHL24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-211 amino acids from the Central region of human KLHL24.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLHL24 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL24
Synonyms DRE1
Function Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity).
Cellular Location Perikaryon. Cell projection, axon {ECO:0000250|UniProtKB:Q56A24}. Cytoplasm {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27889062}. Cell junction, desmosome. Cell junction, adherens junction
Tissue Location Expressed in the skin (PubMed:27889062, PubMed:27798626). Found in keratinocytes, dermal fibroblasts, and melanocytes (PubMed:27889062). Basal-layer keratinocytes have lower KLHL24 expression than suprabasal keratinocytes (PubMed:27798626).
Research Areas
Citations (0)

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KLHL24 is specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.


Laezza, F., et al. Neuropharmacology 55(7):1131-1139(2008)
Laezza, F., et al. Mol. Cell. Neurosci. 34(4):539-550(2007)

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Cat# AP5238c
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