|Application ||WB, IHC-P, E|
|Calculated MW||37432 Da|
|Antigen Region||298-326 aa|
|Other Names||DNA-directed RNA polymerase I subunit RPA43, Twist neighbor protein, TWISTNB|
|Target/Specificity||This RPA43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-326 amino acids from the C-terminal region of human RPA43.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPA43 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.|
|Cellular Location||Nucleus, nucleolus.|
|Tissue Location||Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues|
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Provided below are standard protocols that you may find useful for product applications.
RPA43 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Yuan, X., et al. EMBO Rep. 3(11):1082-1087(2002)
Kosan, C., et al. Cytogenet. Genome Res. 97 (3-4), 167-170 (2002)
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