|Calculated MW||40,48 KDa|
|Other Names||Fas like protein ;Apoptosis inducing protein TRICK2A/2B ;Apoptosis inducing receptor TRAIL R2 ;CD 262 ;CD262 ;CD262 antigen ;Cytotoxic TRAIL receptor 2 ;Death domain containing receptor for TRAIL/Apo 2L ;Death domain containing receptor for TRAIL/Apo2L ;Death receptor 5 ;DR 5 ;DR5 ;Fas like protein precursor ;KILLER ;KILLER/DR5 ;OTTHUMP00000123492 ;OTTHUMP00000123493 ;p53 regulated DNA damage inducible cell death receptor (killer) ;p53 regulated DNA damage inducible cell death receptor(killer) ;TNF related apoptosis inducing ligand receptor 2 ;TNF related apoptosis inducing ligand receptor 2 ;TNF-related apoptosis-inducing ligand receptor 2 ;TNFRSF10B ;TR10B_HUMAN ;TRAIL R2 ;TRAIL receptor 2 ;TRAIL-R2 ;TRAILR2 ;TRANCER ;TRICK2 ;TRICK2A ;TRICK2B ;TRICKB ;Tumor necrosis factor receptor like protein ZTNFR9 ;Tumor necrosis factor receptor like protein ZTNFR9 ;Tumor necrosis factor receptor superfamily member 10b ;Tumor necrosis factor receptor superfamily, member 10b ;ZTNFR9|
|Format||Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Synonyms||DR5, KILLER, TRAILR2, TRICK2, ZTNFR9|
|Function||Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
Screaton G.R.,et al.Curr. Biol. 7:693-696(1997).
Walczak H.,et al.EMBO J. 16:5386-5397(1997).
Schneider P.,et al.FEBS Lett. 416:329-334(1997).
Chaudhary P.M.,et al.Immunity 7:821-830(1997).
MacFarlane M.,et al.J. Biol. Chem. 272:25417-25420(1997).
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