|Calculated MW||82 KDa|
|Other Names||DNA repair protein XRCC1;RCC;X ray repair complementing defective repair in chinese hamster;X ray repair complementing defective repair in chinese hamster cells 1;X ray Repair Complementing Defective Repair in Chinese Hamster Cells;X ray repair cross complementing protein 1;X ray repair, complementing defective, repair in Chinese hamster;X-ray repair cross-complementing protein 1;XRCC 1;Xrcc1;XRCC1_HUMAN.|
|Format||Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.|
|Cellular Location||Nucleus. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage|
|Tissue Location||Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Thompson L.H.,et al.Mol. Cell. Biol. 10:6160-6171(1990).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Whitehouse C.J.,et al.Cell 104:107-117(2001).
Sano Y.,et al.Ann. Neurol. 55:241-249(2004).
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