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DCLRE1B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DCLRE1B Antibody (Center) AP5426c
    DCLRE1B Antibody (Center)(Cat. #AP5426c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the DCLRE1B antibody detected DCLRE1B protein (arrow).
  • IHC-P - DCLRE1B Antibody (Center) AP5426c
    DCLRE1B Antibody (Center) (Cat. #AP5426c) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DCLRE1B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H816
Other Accession NP_073747.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60002 Da
Antigen Region 208-236 aa
Additional Information
Gene ID 64858
Other Names 5' exonuclease Apollo, 31--, DNA cross-link repair 1B protein, SNM1 homolog B, SNMIB, hSNM1B, DCLRE1B, SNM1B
Target/Specificity This DCLRE1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-236 amino acids from the Central region of human DCLRE1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDCLRE1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SNM1B
Function 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Cellular Location Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome
Citations ( 0 )


DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).


Anders, M., et al. Cell Cycle 8(11):1725-1732(2009) Liu, L., et al. Cell Cycle 8(4):628-638(2009) Freibaum, B.D., et al. J. Biol. Chem. 283(35):23671-23676(2008) Bae, J.B., et al. Oncogene 27(37):5045-5056(2008) Demuth, I., et al. DNA Repair (Amst.) 7(8):1192-1201(2008) Matsuoka, S., et al. Science 316(5828):1160-1166(2007) Lenain, C., et al. Curr. Biol. 16(13):1303-1310(2006) Freibaum, B.D., et al. J. Biol. Chem. 281(22):15033-15036(2006) Ishiai, M., et al. Mol. Cell. Biol. 24(24):10733-10741(2004) Demuth, I., et al. Oncogene 23(53):8611-8618(2004) Dronkert, M.L., et al. Mol. Cell. Biol. 20(13):4553-4561(2000)

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$ 325.00
$ 109.00
Cat# AP5426c
Availability: In Stock
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