- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Reactivity||Human, Hamster, Mouse|
|Calculated MW||129477 Da|
|Antigen Region||589-616 aa|
|Other Names||Phospholipid-transporting ATPase IG, ATPase IQ, ATPase class VI type 11C, P4-ATPase flippase complex alpha subunit ATP11C, ATP11C, ATPIG, ATPIQ|
|Target/Specificity||This ATP11C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of human ATP11C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP11C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (PubMed:26944472). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B|
|Tissue Location||Widely expressed.|
Provided below are standard protocols that you may find useful for product applications.
The function of ATP11C remains unknown.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Andrew Nesbit, M., et al. Genomics 84(6):1060-1070(2004)
Halleck, M.S., et al. Physiol. Genomics 1(3):139-150(1999)
Yokoi, H., et al. Genomics 20(3):404-411(1994)
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