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ATP11C Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ATP11C Antibody (Center) AP5446c
    ATP11C Antibody (Center) (Cat.#AP5446c) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the ATP11C antibody detected ATP11C protein (arrow).
  • WB - ATP11C Antibody (Center) AP5446c
    ATP11C Antibody (Center) (Cat.#AP5446c) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the ATP11C antibody detected the ATP11C protein (arrow).
  • IHC-P - ATP11C Antibody (Center) AP5446c
    ATP11C Antibody (Center (Cat. #AP5446c) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ATP11C Antibody (Center for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - ATP11C Antibody (Center) AP5446c
    ATP11C Antibody (Center) (Cat. #AP5446c) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NB49
Other Accession NP_001010986.1
Reactivity Human, Hamster, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 129477 Da
Antigen Region 589-616 aa
Additional Information
Gene ID 286410
Other Names Phospholipid-transporting ATPase IG, ATPase IQ, ATPase class VI type 11C, P4-ATPase flippase complex alpha subunit ATP11C, ATP11C, ATPIG, ATPIQ
Target/Specificity This ATP11C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of human ATP11C.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsATP11C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP11C
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (PubMed:26944472). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B
Tissue Location Widely expressed.
Research Areas
Citations ( 0 )


The function of ATP11C remains unknown.


Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Andrew Nesbit, M., et al. Genomics 84(6):1060-1070(2004)
Halleck, M.S., et al. Physiol. Genomics 1(3):139-150(1999)
Yokoi, H., et al. Genomics 20(3):404-411(1994)

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$ 325.00
$ 109.00
Cat# AP5446c
Availability: In Stock
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