|Application ||WB, IHC-P, E|
|Calculated MW||28891 Da|
|Antigen Region||101-128 aa|
|Other Names||Indolethylamine N-methyltransferase, Indolamine N-methyltransferase, Aromatic alkylamine N-methyltransferase, Amine N-methyltransferase, Arylamine N-methyltransferase, Thioether S-methyltransferase, TEMT, INMT|
|Target/Specificity||This INMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-128 amino acids from the Central region of human INMT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.|
|Tissue Location||Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain.|
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Provided below are standard protocols that you may find useful for product applications.
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. [provided by RefSeq].
Kim, Y.H., et al. Exp. Mol. Med. 33(1):23-28(2001)
Thompson, M.A., et al. Genomics 61(3):285-297(1999)
Strahilevitz, M., et al. Biol. Psychiatry 12(2):171-180(1977)
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