|Application ||WB, IHC-P, E|
|Calculated MW||27986 Da|
|Antigen Region||39-66 aa|
|Other Names||CD99 antigen-like protein 2, MIC2-like protein 1, CD99, CD99L2, MIC2L1|
|Target/Specificity||This CD99L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human CD99L2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD99L2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein; Extracellular side. Cell junction|
|Tissue Location||Expressed in many tissues, with low expression in thymus.|
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Provided below are standard protocols that you may find useful for product applications.
CD99L2 may function as a homophilic adhesion molecule. It functions in leukocyte-endothelial cell interactions during leukocyte extravasation, and in particular, at the diapedesis step. Does not seem to be involved in docking of leukocytes to the vessel wall or in lymphocyte diapedesis (By similarity).
Suh, Y.H., et al. Gene 307, 63-76 (2003)
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