|Application ||FC, WB, E|
|Other Accession||Q04744, Q17R00, NP_004089.1|
|Calculated MW||28303 Da|
|Antigen Region||111-138 aa|
|Other Names||Homeobox protein EMX2, Empty spiracles homolog 2, Empty spiracles-like protein 2, EMX2|
|Target/Specificity||This EMX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the Central region of human EMX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EMX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.|
|Tissue Location||Cerebral cortex.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Inkster, B., et al. Neuroimage (2010) In press :
Bayatti, N., et al. Eur. J. Neurosci. 28(8):1449-1456(2008)
Merello, E., et al. Am. J. Med. Genet. A 146A (9), 1142-1150 (2008) :
Treloar, S.A., et al. Mol. Hum. Reprod. 13(8):587-594(2007)
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