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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TRIM50 Antibody (C-term)   

TRIM50 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TRIM50 Antibody (C-term) AP5637b
    TRIM50 Antibody (C-term) (Cat. #AP5637b) western blot analysis in Jurkat cell line lysates (15ug/lane).This demonstrates the TRIM50 antibody detected the TRIM50 protein (arrow).
  • IHC-P - TRIM50 Antibody (C-term) AP5637b
    TRIM50 Antibody (C-term) (Cat. #AP5637b) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TRIM50 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - TRIM50 Antibody (C-term) AP5637b
    TRIM50 Antibody (C-term) (Cat. #AP5637b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86XT4
Other Accession NP_835226.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54774 Da
Antigen Region 354-383 aa
Additional Information
Gene ID 135892
Other Names E3 ubiquitin-protein ligase TRIM50, 632-, Tripartite motif-containing protein 50, TRIM50, TRIM50A
Target/Specificity This TRIM50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-383 amino acids from the C-terminal region of human TRIM50.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM50 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM50
Synonyms TRIM50A
Function E3 ubiquitin-protein ligase that ubiquitinates Beclin- 1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.
Cellular Location Cytoplasm Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins.
Research Areas
Citations (0)

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TRIM50 belongs to the TRIM/RBCC family. It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain and 1 RING-type zinc finger. TRIM50 is an E3 ubiquitin-protein ligase.


Micale, L., et al. Eur. J. Hum. Genet. 16(9):1038-1049(2008)

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$ 325.00
$ 109.00
Cat# AP5637b
Availability: In Stock
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