|Application ||WB, E|
|Other Accession||A2VDW9, NP_036613.2|
|Calculated MW||58023 Da|
|Antigen Region||76-103 aa|
|Other Names||Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3|
|Target/Specificity||This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IKZF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
Billot, K., et al. Leuk. Res. 34(3):289-293(2010)
Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.