|Application ||FC, WB, E|
|Calculated MW||136685 Da|
|Antigen Region||544-572 aa|
|Other Names||WD repeat-containing protein 11, Bromodomain and WD repeat-containing protein 2, WD repeat-containing protein 15, WDR11, BRWD2, KIAA1351, WDR15|
|Target/Specificity||This BRWD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 544-572 amino acids from the Central region of human BRWD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BRWD2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BRWD2, KIAA1351, WDR15|
|Function||Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin- mediated capture of vesicles generated using AP-1 (PubMed:29426865).|
|Cellular Location||Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Note=Shuttles from the cilium to the nucleus in response to Hh signaling (PubMed:29263200). Might be shuttling between the nucleus and the cytoplasm (PubMed:20887964).|
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Provided below are standard protocols that you may find useful for product applications.
WDR11 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
Katoh, M., et al. Int. J. Mol. Med. 11(5):579-583(2003)
Katoh, M., et al. Int. J. Oncol. 22(5):1155-1159(2003)
Chernova, O.B., et al. Oncogene 20(38):5378-5392(2001)
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