|Application ||WB, IHC-P, E|
|Other Accession||NP_000152.1, NP_001019195.1, NP_001019242.1, NP_001019241.1|
|Calculated MW||27903 Da|
|Antigen Region||39-67 aa|
|Other Names||GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I, GCH1, DYT5, GCH|
|Target/Specificity||This GCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-67 amino acids from the N-terminal region of human GCH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).|
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