- CITATIONS: 1
|Application ||WB, E|
|Other Accession||Q8HXX6, NP_000396.2|
|Calculated MW||20838 Da|
|Antigen Region||25-54 aa|
|Other Names||Ganglioside GM2 activator, Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, Ganglioside GM2 activator isoform short, GM2A|
|Target/Specificity||This GM2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids of human GM2A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GM2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.|
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