- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||28138 Da|
|Antigen Region||236-265 aa|
|Other Names||Homeobox protein CDX-1, Caudal-type homeobox protein 1, CDX1|
|Target/Specificity||This CDX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-265 amino acids from the C-terminal region of human CDX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).|
|Tissue Location||Intestinal epithelium.|
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.
Domon-Dell, C., et al., Oncogene 22(39):7913-7921 (2003).
Suh, E.R., et al., J. Biol. Chem. 277(39):35795-35800 (2002).
Mizoshita, T., et al., Gastric Cancer 4(4):185-191 (2001).
Mallo, G.V., et al., Int. J. Cancer 74(1):35-44 (1997).
Bonner, C.A., et al., Genomics 28(2):206-211 (1995).
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