- CITATIONS: 2
|Application ||WB, E|
|Calculated MW||41623 Da|
|Antigen Region||8-37 aa|
|Other Names||Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6, S1PR4, EDG6|
|Target/Specificity||This EDG6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human EDG6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EDG6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung|
Provided below are standard protocols that you may find useful for product applications.
EDG6 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. It participates in endothelial differentiation, and may regulate lymphocyte cell signaling. It is a member of the lysophospholipid/lysosphingolipid receptor family.
Contos, J.J., et al., FEBS Lett. 531(1):99-102 (2002).
Yamazaki, Y., et al., Biochem. Biophys. Res. Commun. 268(2):583-589 (2000).
Graler, M.H., et al., Genomics 53(2):164-169 (1998).
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