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MAGEA12 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAGEA12 Antibody (N-term) AP6162a
    MAGEA12 Antibody (S96) (Cat. #AP6162a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MAGEA12 antibody detected the MAGEA12 protein (arrow).
  • IHC-P - MAGEA12 Antibody (N-term) AP6162a
    MAGEA12 antibody (N-term) (Cat. #AP6162a)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MAGEA12 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43365
Other Accession NP_005358
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 81-108 aa
Additional Information
Other Names Melanoma-associated antigen 12, Cancer/testis antigen 112, CT112, MAGE-12 antigen, MAGE12F antigen, MAGEA12, MAGE12
Target/Specificity This MAGEA12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the N-terminal region of human MAGEA12.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAGEA12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGEA12
Synonyms MAGE12
Function Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.
Tissue Location Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes EMBL; L18877; AAA19023.1; -; Genomic_DNA EMBL; U82671; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BT007108; AAP35772.1; -; mRNA EMBL; CR541775; CAG46574.1; -; mRNA EMBL; AK314168; BAG36852.1; -; mRNA EMBL; CH471169; EAW99432.1; -; Genomic_DNA EMBL; BC003408; AAH03408.1; -; mRNA CCDS; CCDS76048.1; - PIR; I54519; I54519 RefSeq; NP_001159858.1; NM_001166386.3 RefSeq; NP_001159859.1; NM_001166387.3 RefSeq; NP_005358.2; NM_005367.6 UniGene; Hs.169246; - ProteinModelPortal; P43365; - SMR; P43365; - BioGrid; 110285; 26 IntAct; P43365; 25 STRING; 9606.ENSP00000350592; - iPTMnet; P43365; - PhosphoSitePlus; P43365; - BioMuta; MAGEA12; - DMDM; 14286145; - EPD; P43365; - jPOST; P43365; - PaxDb; P43365; - PeptideAtlas; P43365; - PRIDE; P43365; - ProteomicsDB; 55628; - DNASU; 4111; - Ensembl; ENST00000357916; ENSP00000350592; ENSG00000213401 Ensembl; ENST00000393869; ENSP00000377447; ENSG00000213401 Ensembl; ENST00000393900; ENSP00000377478; ENSG00000213401 GeneID; 4111; - KEGG; hsa:4111; - UCSC; uc004fgc.3; human CTD; 4111; - DisGeNET; 4111; - EuPathDB; HostDB:ENSG00000213401.8; - GeneCards; MAGEA12; - HGNC; HGNC:6799; MAGEA12 MIM; 300177; gene neXtProt; NX_P43365; - OpenTargets; ENSG00000213401; - PharmGKB; PA30545; - eggNOG; KOG4562; Eukaryota eggNOG; ENOG4111S70; LUCA GeneTree; ENSGT00940000164673; - HOGENOM; HOG000231161; - HOVERGEN; HBG006315; - InParanoid; P43365; - OMA; PPWSESE; - OrthoDB; 1195799at2759; - PhylomeDB; P43365; - TreeFam; TF328505; - ChiTaRS; MAGEA12; human GeneWiki; MAGEA12; - GenomeRNAi; 4111; - PRO; PR:P43365; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000213401; Expressed in 30 organ(s), highest expression level in material anatomical entity Genevisible; P43365; HS InterPro; IPR037445; MAGE InterPro; IPR021072; MAGE_N InterPro; IPR002190; MHD_dom PANTHER; PTHR11736; PTHR11736; 1 Pfam; PF01454; MAGE; 1 Pfam; PF12440; MAGE_N; 1 SMART; SM01373; MAGE; 1 SMART; SM01392; MAGE_N; 1 PROSITE; PS50838; MAGE; 1 1: Evidence at protein level; Complete proteome; Polymorphism; Reference proteome; Tumor antigen CHAIN 1 314 Melanoma-associated antigen 12 /FTId=PRO_0000156711 DOMAIN 109 308 MAGE. {ECO:0000255|PROSITE- ProRule:PRU00127} COMPBIAS 40 43 Poly-Ser VARIANT 57 57 E -> D (in dbSNP:rs16996512) /FTId=VAR_053498 CONFLICT 10 10 C -> S (in Ref. 2). CONFLICT 187 187 D -> A (in Ref. 1; AAA19023) CONFLICT 300 300 S -> P (in Ref. 1; AAA19023) SEQUENCE 314 AA; 34836 MW; 7E00F7CECD8F6568 CRC64; MPLEQRSQHC KPEEGLEAQG EALGLVGAQA PATEEQETAS SSSTLVEVTL REVPAAESPS PPHSPQGAST LPTTINYTLW SQSDEGSSNE EQEGPSTFPD LETSFQVALS RKMAELVHFL LLKYRAREPF TKAEMLGSVI RNFQDFFPVI FSKASEYLQL VFGIEVVEVV RIGHLYILVT CLGLSYDGLL GDNQIVPKTG LLIIVLAIIA KEGDCAPEEK IWEELSVLEA SDGREDSVFA HPRKLLTQDL VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHL LKISGGPHIS YPPLHEWAFR EGEE
Research Areas
Citations (0)

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MAGEA12 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This gene is expressed in various tumors and tumor cell lines from different tissue origins, but not detected in normal tissues, except testis. The function of this gene is unknown. This and other MAGE genes form a gene cluster at chromosome Xq28 region.


Mallon, A.M., et al., Genome Res. 10(6):758-775 (2000).
Rogner, U.C., et al., Genomics 29(3):725-731 (1995).
Ding, M., et al., Biochem. Biophys. Res. Commun. 202(1):549-555 (1994).
De Smet, C., et al., Immunogenetics 39(2):121-129 (1994).
De Plaen, E., et al., Immunogenetics 40(5):360-369 (1994).

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$ 325.00
$ 109.00
Cat# AP6162a
Availability: In Stock

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