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MAGEB2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAGEB2 Antibody (N-term) AP6172a
    Western blot analysis of MAGEB2(arrow) using rabbit polyclonal MAGEB2 Antibody (Cat.#AP6172a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAGEB2 gene (Lane 2)(Origene Technologies).
  • IHC-P - MAGEB2 Antibody (N-term) AP6172a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15479
Other Accession NP_002355
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 4-33 aa
Additional Information
Other Names Melanoma-associated antigen B2, Cancer/testis antigen 32, CT32, DSS-AHC critical interval MAGE superfamily 6, DAM6, MAGE XP-2 antigen, MAGE-B2 antigen, MAGEB2
Target/Specificity This MAGEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human MAGEB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAGEB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Tissue Location Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types EMBL; U93163; AAC23617.1; -; Genomic_DNA EMBL; AF015766; AAD01565.1; -; mRNA EMBL; AC005185; AAD10635.1; -; Genomic_DNA EMBL; BC026071; AAH26071.1; -; mRNA CCDS; CCDS14219.1; - RefSeq; NP_002355.2; NM_002364.4 RefSeq; XP_011543814.1; XM_011545512.1 UniGene; Hs.113824; - ProteinModelPortal; O15479; - SMR; O15479; - BioGrid; 110287; 30 IntAct; O15479; 46 MINT; O15479; - STRING; 9606.ENSP00000368273; - iPTMnet; O15479; - PhosphoSitePlus; O15479; - BioMuta; MAGEB2; - EPD; O15479; - MaxQB; O15479; - PaxDb; O15479; - PeptideAtlas; O15479; - PRIDE; O15479; - ProteomicsDB; 48684; - DNASU; 4113; - Ensembl; ENST00000378988; ENSP00000368273; ENSG00000099399 GeneID; 4113; - KEGG; hsa:4113; - UCSC; uc004dbz.4; human CTD; 4113; - DisGeNET; 4113; - EuPathDB; HostDB:ENSG00000099399.5; - GeneCards; MAGEB2; - H-InvDB; HIX0016713; - HGNC; HGNC:6809; MAGEB2 HPA; HPA065224; - HPA; HPA074544; - HPA; HPA075519; - MIM; 300098; gene neXtProt; NX_O15479; - OpenTargets; ENSG00000099399; - PharmGKB; PA30555; - eggNOG; KOG4562; Eukaryota eggNOG; ENOG4111S70; LUCA GeneTree; ENSGT00760000118824; - HOGENOM; HOG000231161; - HOVERGEN; HBG006315; - InParanoid; O15479; - OMA; RFREHFP; - OrthoDB; EOG091G0TJ0; - PhylomeDB; O15479; - TreeFam; TF328505; - GeneWiki; MAGEB2; - GenomeRNAi; 4113; - PRO; PR:O15479; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000099399; - CleanEx; HS_MAGEB2; - Genevisible; O15479; HS InterPro; IPR037445; MAGE InterPro; IPR021072; MAGE_N InterPro; IPR002190; MHD_dom PANTHER; PTHR11736; PTHR11736; 1 Pfam; PF01454; MAGE; 1 Pfam; PF12440; MAGE_N; 1 SMART; SM01373; MAGE; 1 SMART; SM01392; MAGE_N; 1 PROSITE; PS50838; MAGE; 1 1: Evidence at protein level; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Tumor antigen; Ubl conjugation pathway CHAIN 1 319 Melanoma-associated antigen B2 /FTId=PRO_0000156713 DOMAIN 111 310 MAGE. {ECO:0000255|PROSITE- ProRule:PRU00127} MOD_RES 77 77 Phosphoserine MOD_RES 105 105 Phosphoserine VARIANT 61 61 E -> K (in dbSNP:rs2529541) /FTId=VAR_027675 VARIANT 318 318 G -> R (in dbSNP:rs5972090) /FTId=VAR_027676 SEQUENCE 319 AA; 35277 MW; CF0BD27A832D5CBB CRC64; MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP CAFPTHYEEA LKDEEKAGV
Research Areas
Citations (0)

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MAGEB2 is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.


Park, J.H., et al., Mol. Cells 13(2):288-295 (2002).
Lurquin, C., et al., Genomics 46(3):397-408 (1997).
Dabovic, B., et al., Mamm. Genome 6(9):571-580 (1995).

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$ 325.00
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Cat# AP6172a
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