OASL Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- CITATIONS: 3
|Application ||WB, IHC-P, E|
|Calculated MW||59226 Da|
|Antigen Region||484-514 aa|
|Other Names||2'-5'-oligoadenylate synthase-like protein, 2'-5'-OAS-related protein, 2'-5'-OAS-RP, 59 kDa 2'-5'-oligoadenylate synthase-like protein, Thyroid receptor-interacting protein 14, TR-interacting protein 14, TRIP-14, p59 OASL, p59OASL, OASL, TRIP14|
|Target/Specificity||This OASL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OASL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.|
|Cellular Location||Isoform p56: Nucleus, nucleolus. Cytoplasm.|
|Tissue Location||Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis|
Provided below are standard protocols that you may find useful for product applications.
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
Hovnanian, A., et al., Genomics 56(3):362-363 (1999).
Rebouillat, D., et al., Eur. J. Biochem. 257(2):319-330 (1998).
Hartmann, R., et al., Nucleic Acids Res. 26(18):4121-4128 (1998).
Lee, J.W., et al., Mol. Endocrinol. 9(2):243-254 (1995).
Mackay, V., et al., J. Biol. Chem. 251(12):3716-3719 (1976).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.