|Application ||WB, E|
|Calculated MW||71115 Da|
|Antigen Region||508-538 aa|
|Other Names||Poly [ADP-ribose] polymerase 6, PARP-6, ADP-ribosyltransferase diphtheria toxin-like 17, ARTD17, PARP6|
|Target/Specificity||This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-538 amino acids from the C-terminal region of human Parp6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Parp6 Antibody (C-term 503) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins.|
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Provided below are standard protocols that you may find useful for product applications.
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Ame,J.C., Bioessays 26 (8), 882-893 (2004)
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